Figure 2.

Histopathological analysis of liver in experimental bone marrow (BM) chimeras after HS/T. Liver sections from wild-type and experimental BM chimeras [TLR4^−/− and dendritic cell (DC)-TLR4^−/−], left untreated (control) or 6 h after HS/T were stained with H&E (A) as described in Section “Materials and Methods.” Images are representative of 7–10 mice per treatment group. Arrows indicate areas of necrosis in liver. Panel (B) shows the quantification of organ damage (*P < 0.001, analyzed by Student’s t-test).