Figure 3.

Histopathological analysis of lung in experimental bone marrow (BM) chimeras after HS/T. Lung sections from wild-type (WT) and experimental BM chimeras [TLR4^−/− and dendritic cell (DC)-TLR4^−/−], left untreated (control) or 6 h after HS/T were stained with H&E (A) as described in Section “Materials and Methods.” Images are representative of 7–10 mice per treatment group. Arrow heads point to inflammatory cell infiltration in the lung. Panel (B) shows the quantification of organ damage (*P < 0.001, analyzed by Student’s t-test).