Figure 5.

MIG and KC are early drivers of inflammation in a mouse model of HS/T. Dynamic changes in 20 cytokines and chemokines were measured in wild-type (WT) B6 mice subjected to HS/T at 0, 2 (end of shock), 3, 6, and 24 h as described in Section “Materials and Methods.” Using the time courses of circulating inflammatory mediators, Dynamic Bayesian Network (DBN) inference was used to determine possible network structures that exhibit self-feedback as central nodes. DBN inference suggested a primary network driven with core motifs consisting of MIG and KC, each of which drives its own expression and were inferred to affect the downstream production of IP-10, MCP-1, and IL-10 (n = 6 independent experiments).