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. 2017 Dec 4;3:35. doi: 10.1038/s41540-017-0036-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Expression profiles of DOCK5 in 12 data sets. The time-series responses of DOCK5 in the 12 data sets are shown together with the adjusted p-value after ANOVA time series analysis and significant trend after Jonckheere trend analysis. DOCK5 can be observed to be significantly up-regulated in 1 and down-regulated in 5 data sets - “Significant” is defined to be statistically significant after Jonckheere test and requiring an overall fold change of 1.2 or greater between measurements at time t = 0 day and the last time-point in the time-series