Fig. 4.

Effect of DOCK5 knockout on the replication of influenza virus in A549 cells. H1N1 virus (a) and H3N2 (b) virus were inoculated at MOI of 0.0005 TCID₅₀/cell and 0.005 TCID₅₀/cell, respectively, at day 0. The replication of the virus in the wild type and DOCK5 knockout A549 cells was determined by titration of the culture supernatants over 3 days using a TCID50 assay. Error bars represent standard deviation (SD). c Intersections among six selected DOCK5-ko DEG signatures are shown. The matrix of solid and empty circles at the bottom illustrates the “presence” (solid green) or “absence” (empty) of the gene sets in each intersection. The numbers to the right of the matrix are set sizes. The colored bars on the top of the matrix represent the intersection sizes with the color intensity showing the p-value significance. The intersections are ordered by p-values of the super exact test. The corresponding function for each gene set was also shown at the bottom and on the right hand-side of the matrix