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. 2017 Dec 4;3:35. doi: 10.1038/s41540-017-0036-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Validation of the changes of expression of DOCK5 key targets under different scenarios as combinations of the DOCK5 perturbations (DOCK5-wt and DOCK5-ko) and virus infections (H1N1 and H3N2 infections) by RT-qPCR at day 1 and day 2 post infection. The expression of ISG20 (a, b), JUN (c, d) and VAMP5 (e, f) was measured by RT-qPCR during H1N1 (a, c, e) and H3N2 (b, d, f) infections. Difference in expression of each gene between DOCK5-wildtype (WT) and DOCK5-ko (DOCK5) during either H1N1 or H3N2 infection was assessed by t-test. Significant differences were indicated by *(p < 0.05), **(p < 0.01) and ***(p < 0.005)