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. 2017 Nov 29;8:1642. doi: 10.3389/fimmu.2017.01642

Table 1.

Engulfment machinery in professional and non-professional phagocytes in C. elegans, D. melanogaster, and mammals.

C. elegans D. melanogaster Mammals
Engulfment receptors

  • CED-7

  • αPAT-3/INA-1

  • CED-1

  • C03F11.3

  • ND

  • ND

  • ND

  • ND

  • ND

  • ND

  • ND

  • ND

  • ND

  • ND

  • ND

  • αPS3βPS/βν

  • Draper

  • Croquemort

  • NimC4/SIMU

  • ND

  • ND

  • ND

  • ND

  • ND

  • ND

  • ND

  • ND

  • ND

  • ABCA1/7

  • αvβ5/β3 Integrin

  • Megf10/SCARF1

  • CD36

  • ND

  • BAI-1

  • BAI-3

  • TIM-1

  • TIM-4

  • MerTK

  • Fc Receptor

  • Stablin 2

  • LRP/1

  • KIM-1
Adaptor proteins

  • CED-2

  • CED-5

  • CED-6

  • CED-12

  • ND

  • Mbc/Sponge

  • Ced-6

  • Ced-12

  • CrkII

  • Dock180

  • GULP

  • ELMO 1(2)
GTPases

  • Ced-10

  • Cdc-42

  • Rac1

  • Rac2

  • Cdc42

  • Rac1

  • Cdc42

Orthologs based on literature review. ND indicates ortholog not determined.