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. 2017 Nov 29;8:1676. doi: 10.3389/fimmu.2017.01676

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Copyright © 2017 Clayton, Vallejo, Davies, Sirvent and Polak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Unique transcriptome of LCs distinguishes them from DCs and macrophages. (A) LCs share characteristics with macrophages (yolk sac origin, tissue residence) and DCs (priming T lymphocytes, migration to the lymph nodes). (B) Hierarchical clustering analysis of GSE60317 dataset. Samples include LCs (yellow box), CD14⁺ dermal DCs (orange box), and cutaneous macrophages (blue box) total RNA expression data. Data obtained from GEO (Illumina Human WG-6 v3.0) were log transformed and normalized before using all probes for hierarchical clustering analysis (hclust package, R: Euclidean distance and complete clustering). The cluster analysis revealed LCs to be transcriptionally distinct from both dermal CD14⁺ dendritic cells and macrophages.