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Transcriptomic programs initiated in LCs by the signaling from the epidermis are controlled by GRNs. PU.1-GRN controls LC development and steady state, while Interferon Regulatory Factor (IRF)–GRN regulates LC activation and antigen presentation in MHC class I and II. NF-κB system is involved in both induction of tolerance and activation. A switch between PU.1 controlled GRN and IRF–NF-κB–GRN regulates LC function, and determines whether it induces tolerance or immune activation.
