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. 2017 Nov 29;10:395. doi: 10.3389/fnmol.2017.00395

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Copyright © 2017 Zhang, Zhan, Li, Xing, Jiang, Chen, Shi and An.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alternate-day fasting alleviated the loss of AQP4 polarity in the cerebral cortex of APP/PS1 mice. Immunofluorescence staining for AQP4 showed stronger intensity on the astrocytic endfeet in the brains of WT mice with or without ADF treatment. In the brains of APP/PS1 mice, immunofluorescence staining for AQP4 showed AQP4 localization was severely perturbed, exhibiting weaker intensity on the astrocytic endfeet and stronger intensity on the somal. After the ADF intervention, the polarity of AQP4 recovered in the APP/PS1 mice brains.