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. 2017 Nov 29;10:395. doi: 10.3389/fnmol.2017.00395

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Copyright © 2017 Zhang, Zhan, Li, Xing, Jiang, Chen, Shi and An.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of miR-130a on transcriptional activity of AQP4 and the AQP4-M1/M23 ratio. The miR-130a mimic and inhibitor were separately used to improve and inhibit miR-130a expression. The relative expression of AQP4 mRNA (A) and proteins (B,C) were analyzed by qRT-PCR (U6 as a reference standard) and Western blot, respectively, in miR-130a mimic and inhibitor-treated cells (n = 6; mean ± SD; one-way ANOVA followed by LSD multiple comparison tests; ^∗p < 0.05, ^∗∗p < 0.01 vs. mimic control group, ^##p < 0.01 vs. inhibitor control group).