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. 2017 Nov 29;11:381. doi: 10.3389/fncel.2017.00381

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Copyright © 2017 Li, Chen, Zhao, Luo, Hou, Li, He, Zhou and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protective role of VEGF against inflammation in spinal cord in rats after ST. (A) Immunofluorescence staining for Ibal-1 to label microglia (red, A1–A6) in the L3 segment of the rat spinal cord; (B) The number of Ibal 1-positive cells increased in the four injured groups compared with that in the sham groups. There was no significant difference in the Ibal-1 positive cell number between the P1 and P28 sham groups. Among the four injured groups, the number in the P28 + PBS group was significantly higher than that in the P1 + PBS group or P28 + VEGF group, the number in the P1 + inhibitor group significantly increased compared with that in the P1 + PBS group. ^*P < 0.05; ^**P < 0.01; n = 6.