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. 2017 Nov 29;8:886. doi: 10.3389/fphar.2017.00886

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Copyright © 2017 Li, Liu, Li, Li, Huang, Zhou, Zhang, Wang, Dong, Zhang, Yang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The ability of spatial information acquisition assessed by Place trial in type 2 diabetic Goto–Kakizaki (GK) rats and non-diabetic Wistar rats 5 months after sevoflurane (SEV) or sham (control, CON) exposure. There was no difference across four experimental groups in swimming speed throughout 4 consecutive days (A). However, both groups of GK rats took longer to locate the submerged platform than Wistar rats on the last two trials, and the GK + SEV rats spent more time to find the submerged platform than GK + CON rats (B). Data are presented as mean ± SE (n = 10 for each group). ^∗P < 0.05 vs. respective Wistar rats; ^†P < 0.05 vs. GK+CON rats.