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. 2017 Nov 29;8:886. doi: 10.3389/fphar.2017.00886

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Copyright © 2017 Li, Liu, Li, Li, Huang, Zhou, Zhang, Wang, Dong, Zhang, Yang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The memory retention capabilities assessed by Probe trial in type 2 diabetic Goto–Kakizaki (GK) rats and non-diabetic Wistar rats 5 months after sevoflurane (SEV) or sham (control, CON) exposure. The number of original platform (the third quadrant) crossings (A) and the percent time spent in the third quadrant (B) were reduced in both groups of GK rats than Wistar rats. Moreover, the number of platform crossings and the percent time spent in the third quadrant were less in GK + SEV rats than those in GK + CON rats. Data are presented as mean ± SE (n = 10 for each group). ^∗P < 0.05 vs. respective Wistar rats; ^†P < 0.05 vs. GK+CON rats.