Table 2.
Q10 coefficients for reaction fluxes
Reaction and metabolite abbreviations are BiGG database identifiers. GGCT, glutamyl cyclotransferase; GLUCYS, γ-glutamylcysteine synthetase; GTHS, glutathione synthase; GLNS, glutamine synthetase; ADK1 , adenylase kinase; PPA, inorganic diphosphatase; PGK, phosphoglycerate kinase; ENO , enolase; PGM, phosphoglycerate mutase; ADA, adenosine deaminase; PYK, pyruvate kinase; HEX1, hexokinase; AMPDA, adenosine monophosphate deaminase; GAPD, glyceraldehyde-3-phosphate dehydrogenase; PFK , phosphofructokinase; FBA, fructose-bisphosphate aldolase; TPI, triose-phosphate isomerase; PGI, glucose-6-phosphate isomerase; PEPCK, phosphoenolpyruvate carboxylase; NDPK1, nucleoside-diphosphate kinase (ATP:GDP); NTD11, 5′-nucleotidase (IMP); NTD7, 5′-nucleotidase (AMP); PRPPS, phosphoribosylpyrophosphate synthetase; PDE1, 3′,5′-cyclic-nucleotide phosphodiesterase; ADNCYC, adenylate cyclase; DPGase, diphosphoglycerate phosphatase; GLUN, glutaminase; GUAPRT, guanine phosphoribosyltransferase; NTD9, 5′-nucleotidase (GMP); PUNP3, purine-nucleoside phosphorylase (guanosine); PPM, phosphopentomutase; PUNP5, purine-nucleoside phosphorylase (inosine); OPAHir, 5-oxoproline amidohydrolase (ATP-hydrolyzing); P C, pyruvate carboxylase ; HXPRT, hypoxanthine phosphoribosyltransferase; g lucys , γ-l-glutamyl-l-cysteine; 5 oxpro , 5-oxoproline; gthrd, reduced glutathione; 3pg, 3-phospho-d-glycerate; 13dpg, 3-phospho-d-glyceroyl phosphate; 2pg, 2-phospho-d-glycerate; pep, phosphoenolpyruvate; adn, adenosine; ins, inosine; pyr, pyruvate; g6p, d-glucose 6-phosphate; imp, inositate; g3p, glyceraldehyde 3-phosphate; f6p, d-fructose 6-phosphate; fdp, d-fructose 1,6-bisphosphate; dhap, dihydroxyacetone phosphate; oaa, oxaloacetate; r5p, α-d-ribose 5-phosphate; prpp, 5-phospho-α-d-ribose 1-diphosphate; 23dpg, 2,3-disphospho-d-glycerate; gua, guanine; gsn, guanosine; r1p, α-d-ribose 1-phosphate; hxan, hypoxanthine.
| Reaction | Q10 | R2 | Formula |
|---|---|---|---|
| GGCT | 1.98 | 0.93 | glucys → 5oxpro + cys-L |
| GLUCYS | 2.06 | 0.93 | atp + cys-L + glu-L → adp + glucys + h + pi |
| GTHS | 2.21 | 0.93 | atp + glucys + gly → adp + gthrd + h + pi |
| GLNS | 2.23 | 0.91 | atp + glu-L + nh4 → adp + gln-L + h + pi |
| ADK1 | 2.29 | 0.91 | amp + atp ⇆ 2 adp |
| PPA | 2.40 | 0.94 | h2o + ppi → h + 2 pi |
| PGK | 2.53 | 0.95 | 3pg + atp ⇆ 13dpg + adp |
| ENO | 2.57 | 0.95 | 2pg ⇆ h2o + pep |
| PGM | 2.57 | 0.95 | 2pg ⇆ 3pg |
| ADA | 2.58 | 0.99 | adn + h2o + h → ins + nh4 |
| PYK | 2.59 | 0.95 | adp + h + pep → atp + pyr |
| HEX1 | 2.60 | 0.95 | atp + glc-D → adp + g6p + h |
| AMPDA | 2.62 | 0.99 | amp + h2o + h → imp + nh4 |
| GAPD | 2.63 | 0.95 | g3p + nad + pi ⇆ 13dpg + h + nadh |
| PFK | 2.65 | 0.96 | atp + f6p → adp + fdp + h |
| FBA | 2.65 | 0.96 | fdp ⇆ dhap + g3p |
| TPI | 2.65 | 0.96 | dhap ⇆ g3p |
| PGI | 2.72 | 0.96 | g6p ⇆ f6p |
| PEPCK | 3.04 | 0.93 | gtp + oaa → co2 + gdp + pep |
| NDPK1 | 3.04 | 0.93 | atp + gdp ⇆ adp + gtp |
| NTD11 | 3.60 | 0.91 | h2o + imp → ins + pi |
| NTD7 | 3.70 | 0.91 | amp + h2o → adn + pi |
| PRPPS | 3.78 | 0.93 | atp + r5p ⇆ amp + h + prpp |
| PDE1 | 3.79 | 0.91 | camp + h2o → amp + h |
| ADNCYC | 3.79 | 0.91 | atp → camp + ppi |
| DPGase | 3.79 | 0.91 | 23dpg + h2o → 3pg + pi |
| GLUN | 3.79 | 0.91 | gln-L + h2o → glu-L + nh4 |
| GUAPRT | 3.81 | 0.91 | gua + prpp → gmp + ppi |
| NTD9 | 3.81 | 0.91 | gmp + h2o → gsn + pi |
| PUNP3 | 3.81 | 0.91 | gsn + pi ⇆ gua + r1p |
| PPM | 4.04 | 0.95 | r1p ⇆ r5p |
| PUNP5 | 4.16 | 0.96 | ins + pi ⇆ hxan + r1p |
| OPAHir | 4.26 | 0.92 | 5oxpro + atp + 2 h2o → adp + glu-L + h + pi |
| PC | 4.34 | 0.94 | atp + hco3 + pyr → adp + h + oaa + pi |
| HXPRT | 4.54 | 0.96 | hxan + prpp → imp + ppi |