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The X-ray crystal structure of the drug-resistant mutant (T124N/V165I/T174I) CCD dimer (cyan and green) overlaid with the structure of CCD dimer (gray and yellow) bound to KF116 (magenta). Side chains for drug resistance substitutions (in red) and their corresponding WT residues are shown. Both CCD constructs contained the additional F185K solubilizing substitution.
