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ABR waveforms following XE991 administration. Suppression of the ABR following a 12.5 mg/kg dose of XE991 is illustrated at top. Enhancement is illustrated following a 0.5 mg/kg dose of XE991 at bottom. ABR responses to 110 dB peSPL clicks were recorded at baseline (B; before drug) and 30, 60, and 90 min after drug. ABR waveforms demonstrate that XE991 gradually alters the ABRs over time. Vertical dashed lines represent the baseline latencies of P1, P2, and P4 response peaks.
