Table 1.
In vitro anti-viral activities of favipiravir
| Group | Family | Virus | EC50 (µg/mL) | Reference |
|---|---|---|---|---|
| RNA (−) strand | Orthomyxoviridae | Influenza A (seasonal) | 0.01–0.94 | Furuta, Y. et al. 200221) Sleeman, K. et al. 201022) |
| Influenza A (H5N1) | 0.2–1.9 | Sidwell, R.W. et al. 200725) Sleeman, K. et al. 201022) | ||
| Influenza A (H1N1)pdm09 | 0.13–3.53 | Sleeman, K. et al. 201022) | ||
| Influenza A (H7N9) | 1.4 | Watanabe, T. et al. 201361) | ||
| Influenza B | 0.04–0.8 | Furuta, Y. et al. 200221) Sleeman, K. et al. 201022) | ||
| Influenza C | 0.03–0.06 | Furuta, Y. et al. 200221) | ||
| Bunyaviridae | La Crosse | 5 | Gowen, B.B. et al. 200729) | |
| Punta Toro | 8.6–30 | Gowen, B.B. et al. 2007, 201029,34) | ||
| Rift Valley fever | 4.2–5.0 | Gowen, B.B. et al. 2007, 201029,34) | ||
| Sandfly fever | 4.7–18 | Gowen, B.B. et al. 2007, 201029,34) | ||
| Dobrava | 15 | Buys, K.K. et al. 201135) | ||
| Maporal | 10 | Buys, K.K. et al. 201135) | ||
| Crimean-Congo hemorrhagic fever | 1.1 | Oestereich, L. et al. 201436) | ||
| Prospect Hill | 10 | Buys, K.K. et al. 201135) | ||
| Severe fever thrombocytopenia syndrome | 0.71–1.3 | Tani, H. et al. 201641) | ||
| Arenaviridae | Junin | 0.8–3.0 | Gowen, B.B. et al. 2007, 201029,34) Mendenhall, M. et al. 201131) | |
| Pichinde | 0.9–3.9 | Gowen, B.B. et al. 2007, 201029,34) | ||
| Tacaribe | 0.9–4.1 | Gowen, B.B. et al. 2007, 201029,34) | ||
| Guanarito | 2.4 | Mendenhall, M. et al. 201131) | ||
| Machupo | 2.2 | Mendenhall, M. et al. 201131) | ||
| Lassa | 1.7–11.1 (EC90) | Safronetz, D. et al. 201532) Oestereich, L. et al. 201633) | ||
| Filoviridae | Ebola | 10.5 | Oestereich, L. et al. 201453) Smither, S.J. et al. 201454) | |
| Rhabdoviridae | Rabies | 5.1–7.0 | Yamada, K. et al. 201658) | |
| Paramyxoviridae | Human metapneumovirus | 1.3–6.3 (EC90) | Jochmans, D. et al. 201660) | |
| Respiratory syncytial virus | 41 | Furuta, Y. et al. 200221) | ||
| RNA (+) strand | Flaviviridae | West Nile | 53 | Morrey, J.D. et al. 200844) |
| Yellow fever | 42 | Julander, J.G. et al. 200943) | ||
| Zika virus | 3.5–3.8 | Zmurko J. et al. 201645) | ||
| Togaviridae | Western equine encephalitis | 1.2, 49 (EC90) | Delang, L. et al. 201447) Julander, J.G. et al. 200946) | |
| Venezuelan equine encephalitis | 1.7 | Delang, L. et al. 201447) | ||
| Eastern equine encephalitis | 2.8 | Delang, L. et al. 201447) | ||
| Barmah forest | 2.8 | Delang, L. et al. 201447) | ||
| Ross river | 0.5 | Delang, L. et al. 201447) | ||
| Mayaro | 2.5 | Delang, L. et.al. 201447) | ||
| Chikungunya | 0.3–9.4 | Delang, L. et al. 201447) | ||
| Picornaviridae | Polio | 4.8 | Furuta, Y. et al. 200221) | |
| Rhino | 23 | Furuta, Y. et al. 200221) | ||
| Enterovirus 71 | 23 | Wang, Y. et al. 201650) | ||
| Caliciviridae | Noro | 19–39 | Rocha-pereira, J. et al. 201251) |