Figure 6.

Effects of aqueous extract from the leaves of Aspidosperma pyrifolium and rutin in lung histopathologic changes in VTs-induced peritonitis model. The animals received 100 μL of VTs intraperitoneal and were treated intravenously, at the same time with saline, AE (40, 50 or 60 mg/kg) or rutin (2.5 or 5 mg/kg). Six hours after envenomation induction, the animals were euthanized and had their lungs removed, processed and analyzed by hematoxylin and eosin staining on optical microscope (40×): (A) saline (intraperitoneal) and saline (intravenous); (B) VTs (intraperitoneal) and saline (intravenous); and (C–H) animals treated (intravenous) with: (C) SAAV 50 μL; (D) rutin 2.5 mg/kg; (E) rutin 5 mg/kg (F) AE 40 mg/kg; (G) 50 mg/kg and (H) 60 mg/kg.