Table 2.
Anti-inflammatory activity of aqueous extract (AE) from the leaves of Aspidosperma pyrifolium and rutin against Tityus serrulatus venom-induced peritonitis model.
| Groups | Dose (mg/kg) | Peritoneal Cell Migration (×106 cells/mL) | Inhibition (%) | |
|---|---|---|---|---|
| T. serrulatus venom (7.5 μg/animal) | saline | - | 19.10 ± 1.145 | |
| SAAV | - | 5.875 ± 1.638 *** | 69.6 | |
| AE | 40 | 9.083 ± 1.393 *** | 52.8 | |
| AE | 50 | 8.417 ± 1.207 *** | 56.0 | |
| AE | 60 | 5.250 ± 1.055 *** | 72.7 | |
| T. serrulatus venom (7.5 μg/animal) | saline | - | 19.10 ± 1.145 | |
| SAAV | - | 5.875 ± 1.638 *** | 69.6 | |
| rutin | 2 | 9.300 ± 1.758 *** | 51.3 | |
| rutin | 2.5 | 5.700 ± 0.5612 *** | 70.1 | |
| rutin | 5 | 6.400 ± 1.198 *** | 66.4 | |
Values are mean ± standard deviation (S.D.), n = 5, *** p < 0.001, compared to venom group. SAAV: Serum Arachnid antivenom (1 mg/mL).