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Allosteric pathways analysis between R135K and residues important for NS1 binding.
| Pathway | Length a | Residue b | Subopt c | |||
|---|---|---|---|---|---|---|
| WT | R135K | WT | R135K | WT | R135K | |
| R135(K)-R128 | 38 | 60 | 3 | 8 | 12 | 1 |
| R135(K)-Q131 | 21 | 29 | 2 | 5 | 1 | 1 |
| R135(K)-I142 | 68 | 61 | 4 | 8 | 9 | 0 |
| R135(K)-E143 | 86 | 84 | 4 | 9 | 12 | 1 |
a The length of the shortest pathway of the corresponding residues; b The number of residues involved in the shortest pathway; c The number of suboptimal pathways.
