Figure 4.

Activation state of specific survival pathways in the OB of aged Tg2576 mice. Levels and residue-specific phosphorylation of focal adhesion kinase (FAK), ERK Activator Kinase 1 (MEK)/extracellular signal-regulated kinase (ERK), protein kinase B (Akt), phosphoinositide-dependent protein kinase 1 (PDK1), protein kinase C (PKC), p38 mitogen-activated protein kinase (p38 MAPK), and mitogen-activated protein kinase kinase 4 (SEK1/MKK4), in the OB of aged Tg2576 mice. Equal loading of the gels was assessed by stain free digitalization. Equal loading control and quantitation values have been included in Table S5.