Table 1.

Potential upstream regulators of differential targets detected in our study.

Upstream Regulator	Molecule Type	p-Value	Target Molecules in OB Omics Dataset
CREB1	transcription regulator	0.00000209	APOE, ARC, EGR1, EGR2, FOSB, GNAL, HLA-A, JUNB, NR4A1, NR4A2, NR4A3, RBP4, SCD, ZDHHC23
NFKBIA	transcription regulator	0.00916	BCL2A1, CD82, HLA-A, JUNB, MMP15, NID1, NR4A1
NFKB1	transcription regulator	0.0000748	APOE, APP, BCL2A1, CD82, EGR1, HLA-DMB, NR4A1, TBX21
NFκB (complex)	complex	0.00174	APOE, APP, BCL2A1, CD82, EGR1, GFAP, HLA-A, HLA-DMB, JUNB, KLF3