Figure 9.

Cilia-dependent OFD1/Autophagy signaling. (A) In basal autophagy, ciliogenesis is prevented by the sequestering of IFT20 in autophagosomes and its autophagic degradation. OFD1, a protein that constrains cilium formation at centriolar satellites, is not affected by basal autophagy and ciliogenesis is therefore impaired. (B) Autophagy induced by serum deprivation promotes ciliogenesis through inactivation of OFD1, while sparing IFT20. Autophagy proteins are also confined to this sensory organelle, probably contributing to cilium organization. At the basal body, signals from the cilium stimulate autophagosome nucleation and OFD1 degradation.