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. 2017 Nov 3;18(11):2317. doi: 10.3390/ijms18112317

Figure 1.

Figure 1

The 2158 nucleotide long human HOX transcript antisense RNA (HOTAIR) gene is located within the 12q13 chromosomal region in the HOXC (homeobox C) gene cluster and is transcribed from the antisense strand of the cluster. The promoter of the HOTAIR gene contains binding sites for many transcription factors, including several estrogen response elements (ER) and sites for specificity protein 1 (SP1), nuclear factor kappa B (NF-κB), activator protein 1 (AP1), hypoxia response elements (HRE). TSS–transcription start site; the upper strand of the HOXC cluster is presented in the 5′→3′ orientation as is the HOTAIR promoter; the numbers indicate chromosomal position of the HOXC cluster in bp; arrows show the direction of transcription.