Table 4.
Significantly regulated miRNAs in blood.
| Signal | ||||||
|---|---|---|---|---|---|---|
| miRNA | MCAO | Sham | Fold Change | p-Value | Target Gene | Target mRNA |
| miR-107-5p | 1.08 | 0.19 | 1.85 | 0.022 | 69 | H2afz (M < S) |
| miR-383-5p | 4.26 | 3.39 | 1.83 | 0.024 | 19 | |
| miR-24-1-5p | 2.58 | 1.91 | 1.59 | 0.031 | 21 | |
| mir-191b | 1.06 | 0.41 | 1.57 | 0.004 | ||
| miR-196b-5p | 1.51 | 0.90 | 1.53 | 0.050 | 22 | Ptprc (M < S) |
| miR-3552 | 0.98 | 0.37 | 1.52 | 0.002 | 74 | Srsf2 (M < S) |
| mir-194-1 | 0.20 | 0.99 | −1.72 | 0.017 | ||
miRNAs within ANOVA p-value < 0.05 and |fold change| ≥ 1.5. Signal column shows the log2 value of the mean signal of samples from each group. Fold change ≥ 1.5 indicates upregulation and fold change ≤ −1.5 indicates downregulation in the MCAO group compared with the sham group. Target gene column shows the number of target genes of the mature miRNAs from the database miRDB. Target mRNA column shows the target genes that coincide with the DEGs extracted by DNA microarray analysis of the blood sample. M < S indicates that the mRNA is downregulated in the MCAO group compared with the sham group.