Table 1.
Summary of clinicopathological features of oral squamous cell carcinoma (OSCCs) and immunohistochemical (IHC) expression patterns of NANOG and MIDKINE.
| NANOG | MIDKINE | ||||||
|---|---|---|---|---|---|---|---|
| Total No. | +++ | ++ | +&− | +++ | ++ | +&− | |
| No. of Cases | 62 | 21 | 22 | 19 | 37 | 14 | 11 |
| Tumor sites | |||||||
| Gingiva | 28 | 11 | 8 | 9 | 17 | 5 | 6 |
| Cheek | 6 | 1 | 3 | 2 | 3 | 2 | 1 |
| Palate | 11 | 3 | 6 | 2 | 6 | 5 | 0 |
| Tongue | 10 | 2 | 3 | 5 | 5 | 2 | 3 |
| FOM | 7 | 4 | 2 | 1 | 6 | 0 | 1 |
| Tumor stage | |||||||
| I+II | 27 | 6 | 9 | 12 | 14 | 4 | 9 |
| III+IV | 35 | 15 | 13 | 7 | 23 | 10 | 2 |
| Neck node | |||||||
| Node (−) | 39 | 9 | 14 | 16 | 20 | 8 | 11 |
| Node (+) | 23 | 12 | 8 | 3 | 17 | 6 | 0 |
| Histo grade | |||||||
| Well | 23 | 4 | 4 | 15 | 8 | 5 | 10 |
| Mod + Poor | 39 | 17 | 18 | 4 | 29 | 9 | 1 |
Abbreviations: FOM, floor of mouth; Node (−), negative neck node; Node (+), positive neck node; Well, well-differentiated OSCC; Mod + Poor, moderately- and poorly-differentiated OSCC.