Figure 1.

Workflow of the gene set regularity model. The gene set regularity (GSR) index was computed by converting the gene expression ordering of gene elements in a gene set through the Gene Ontology (GO) term or canonical pathway databases. The genome-wide informativeness of the GSR index was assessed by the accuracy of pattern recognition, classification and prediction by machine learning using binary or multiclass classifications. Functionome analyses were carried out to investigate the pathogenesis of endometriosis (ES), clear cell carcinoma (CCC), endometrioid carcinoma (EC) and endometriosis associated ovarian carcinoma (EAOC) by statistical methods, hierarchical clustering and exploratory factor analysis.