Table 1.
Impact of HCV proteins on promoting various types of death of Huh7.5 hepatoma cells.
| Markers of Cell Death | HCV Proteins | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Core | E1/E2 | NS3 | NS4A/B | NS5A | NS5B | NS3-NS5B | HCV Replicon | ||
| Apoptosis | Caspase-8 | 3.1 1 | ~ 2 | 2.7 | 0.5 | ~ | 0.5 | 1.8 | 1.9 |
| Caspase-9 | 2.1 | ~ | ~ | ~ | 0.5 | 0.5 | ~ | 1.6 | |
| Caspase-3 | 1.6 | 1.6 | 2.6 | ~ | 0.6 | ~ | ~ | 3.2 | |
| TUNEL | 2.0 | 2.2 | ~ | ~ | ~ | ~ | ~ | 2.1 | |
| Auto-phagy | MDC | ~ | 4.1 | 1.8 | 2.9 | 2.9 | 4.8 | 2.1 | 9.3 |
| LC3-II | ~ | 1.3 | ~ | 1.6 | 1.4 | 1.6 | ~ | 2.2 | |
| Necrosis | ~ | ~ | ~ | ~ | 2.1 | ~ | ~ | ~ | |
1 Changes in rates of detection of the respective marker (fold). 2 Symbol “~” denotes absence of a statistically significant effect.