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Schematic diagram showing the mechanisms by which miR-1224-5p regulates silica-induced pulmonary fibrosis. miR-1224-5p targets BECN1, which lead to block PARK2 translocation to mitochondria and impairing mitophagy activity, then accumulating damaged mitochondria. Moreover, the PDGFRs signaling pathway activation mediated by insufficient mitophagy could promote myofibroblast differentiation.
