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. 2017 Nov 9;18(11):2380. doi: 10.3390/ijms18112380

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Activation of canonical Wnt signaling in the OCCM30-fibrin increases the expression of plasminogen. OCCM30 were cultured for three days in a differentiation medium. LiCl increased the plasminogen expression of the transcripts (A) and protein (B) in OCCM30-fibrin. Over-expression of LEF1 increased the expression of plasminogen (C) and the transcriptional reporter activity of the plasminogen promoter (D). Firefly luciferase activities were normalized with the Renilla luciferase activities. Each experiment was repeated two times independently. * Significantly different from the OCCM30-TCD groups (p < 0.05), ^# significantly different from LiCl or LEF1 non-treated group (p < 0.05).