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. 2017 Nov 11;18(11):2396. doi: 10.3390/ijms18112396

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Analysis of 13 genes with potential microRNA–mRNA interactions in the Gene Expression Omnibus (GEO) database. The expression values of: five up-regulated genes (A); and eight down-regulated genes (B) identified from normal and rheumatoid arthritis (RA) osteoblasts were validated in a representative array (GSE77298) of normal and RA synovial tissues from the GEO database. Significant up-regulation of LRRC15 and down-regulation of AKAP12 and RGS5 were observed in the synovial tissues of patients with RA, compared to the normal subjects. * indicated p < 0.05, and n.s. indicated no statistical significance. (Probe ID reference: BDKRB2, 205870_at; CREB5, 229228_at; FGFRL1, 223321_s_at; LRRC15, 213909_at; SESN3, 242899_at; ADAMTS12, 221421_s_at; AKAP12, 231067_s_at; COL5A3, 218975_at; FAM26E, 230254_at; KCTD20, 228299_at; KLHL3, 221221_s_at; RGS5, 209071_s_at; and SERPINB9, 242814_at).