Table 5.

Networks associated with 13 candidate genes differentially expressed in RA osteoblasts.

	Top Diseases and Functions	Score	Focus Molecules	Molecules in Network
1.	Cardiovascular System Development and Function, Cellular Development, Cellular Growth and Proliferation	27	10	↓ADAMTS12, ↓AKAP12, AKT2, BDKRB1, ↑BDKRB2, BMP1, COL5A1, ↓COL5A3, collagen, Collagen type I, ↑CREB5, ERK1/2, ↓FAM26E, FGF2, Fgfr, ↑FGFRL1, FOXO1, GPC1, Hspg2, Kallikrein, ↓KCTD20, KLKB1, MAPK1, mir-25, mir-181, miR-146a-5p, MIR17HG, NOTCH2, NOTCH4, plasminogen activator, Plc beta, PPARG, ↓RGS5, ↑SESN3, TGFB1
2.	Cellular Compromise, Organismal Injury and Abnormalities, Hereditary Disorder	6	3	AKT2, COASY, DOLPP1, FOSB, FOSL2, FURIN, GBP2, H2AFB3, IGSF8, JUND, KEAP1, ↓KLHL3, ↑LRRC15, MAFG, MAPK3, MARK4, miR-3656, miR-423-5p, miR-4537, miR-6825-5p, MRPS27, NOS3, P2RY8, PLEKHM1, PRKCG, RAB11B, SELPLG, ↓SERPINB9, SLC9A1, SMARCD1, TAGLN, UNC119, USF2, WNK2, WNK4

The genes marked in bold were the 13 candidate genes identified in normal and RA osteoblasts.