Table 7.

Two of the networks associated with 434 candidate genes differentially expressed in RA osteoblasts.

Top Diseases and Functions	Score	Focus Molecules	Molecules in Network
Cellular Development, Cellular Growth and Proliferation, Organ Development	38	25	↓AKAP12, Cbp/p300, ↓CDA, ↑CEMIP, ↓CNN1, ↑CRLF1, ↓DOCK10, E2f, EGLN, ↑EPHA4, ↓EPHA5, ↑FGFRL1, ↓FHL1, ↓FLT1, GTPase, ↓GUCY1B3, Hedgehog, ↓HGF, ↑ICA1, Importin alpha, ↑ITGA6, ↑ITGB8, ↓LMOD1, ↓MYOCD, ↓NOTCH1, ↓PDLIM3, ↑PHLDA1, ↑PLXNA2, Proinsulin, ↓SCUBE3, Sfk, Smad2/3, ↑SOX9, Vegf, ↑VLDLR
Hereditary Disorder, Immunological Disease, Organismal Injury and Abnormalities	22	17	↑ADM2, ATP6AP1, ATP6V1F, CASP2, CDK2AP2, ↑CMKLR1, CTSA, ↓CYGB, ↑ELFN1, ↓FAM46B, FOXRED2, GPR84, GRM4, ↓HAAO, ↓HEYL, ↓IRX2, ↓KCTD20, ↑KIF26B, LDB1, ↑LRRC15, ↓LRRC32, ↓LYPD1, miR-4656, miR-504-3p, ↑MKX, ↓MX1, PLPPR2, ↓PLPPR4, PPP1CA, RASSF8, ↓SERPINA9, TBC1D22A, TRIM67, TUFT1, ZNF677

The genes marked in bold were the 434 differentially expressed protein-coding genes identified in normal and RA osteoblasts.