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. 2017 Nov 16;18(11):2430. doi: 10.3390/ijms18112430

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Schematic representation of the aptamer-gated DNA nanorobot [151]: the aptamer (magenta) is locked in a double-stranded form by a partially complementary sequence (yellow) and both are grafted on the nanorobot. The payloads (either gold nanoparticles (shown) or antibody fragments) are constrained to remain within the DNA construct and only the recognition of intended target by the aptamer (green) will unlock the DNA nanorobot and enable the delivery of the payload; (B) AFM images of a DNA origami-aptamer construct in the presence of a non-target protein (hLDH; left-hand side) and presence of the target protein (PfLDH; right-hand side) [152]; (C) AFM analysis of a DNA origami equipped with a split aptamer system in the closed (left-hand side) and open (right-hand side) forms [153].