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. 2017 Nov 16;18(11):2430. doi: 10.3390/ijms18112430

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Illustrative examples of aptameric-based systems used as drug delivery systems: (A) encapsulation of aptamer-drug complexes in liposome [205]; (B) antibody-aptamer pincers (AAPs) for selective targeting of HER2 and delivery of DOX [208]; (C) streptavidin serves as the core for the connection of two anti-PSMA aptamers and two siRNA molecules [209]; (D) delivery of the 5-fluorouracil (5-FU; shown in red) drug connected to an aptamer-oligonucleotide scaffold via a photo-cleavable linker (shown in blue) [210]; and (E) chemical structures of tobramycin (red) and DOX (blue).