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Estrogen and progesterone—two main hormones influencing the metabolism and proliferation of uterine smooth muscle cells or uterine fibroid cells. Wnt signaling is one of the most important pathways in uterine fibroid pathophysiology. Excessive production of transforming growth factor β depends greatly on Wnt signals. The drugs influencing the hormonal pathways and their potential site of effect are presented. ER: Estrogen receptor; PR: Progesterone receptor.
