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Reticuline biosynthesis in engineered yeast. TyrH: tyrosine hydroxylase; DODC: l-DOPA decarboxylase; NCS: norcolaurine synthase; CYP80B1: cytochrome P450; CRP: cytochrome P450 reductase; 6-OMT: 6-O-methyltransferase; CNMT: coclurine-N-methyltransferase; 4′-OMT: 4′-O-methyltransferase.
