Table 4.
The frequencies of the RNF213 polymorphisms according to age.
| Genotype | Age < 18 Years | Age ≥ 18 Years | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Controls, n = 102 (%) | Moyamoya, n = 57 (%) | AOR (95% CI) * | p | FDR-P | Controls, n = 151 (%) | Moyamoya, n = 60 (%) | AOR (95% CI) * | p | FDR-P | |
| RNF213 4448G>A | ||||||||||
| GG | 89 (87.3) | 51 (89.5) | 1.000 (reference) | 130 (86.1) | 58 (96.7) | 1.000 (reference) | ||||
| GA | 13 (12.7) | 6 (10.5) | 0.800 (0.284–2.251) | 0.672 | 0.672 | 20 (13.2) | 2 (3.3) | 0.223 (0.050−0.986) | 0.048 | 0.064 |
| AA | 0 | 0 | N/A | N/A | 1 (0.7) | 0 | N/A | N/A | ||
| Dominant (GG vs. GA+AA) | 0.800 (0.284−2.251) | 0.672 | 0.672 | 0.214 (0.048−0.944) | 0.042 | 0.056 | ||||
| RNF213 4810G>A | ||||||||||
| GG | 89 (87.3) | 7 (12.3) | 1.000 (reference) | 1.000 (reference) | ||||||
| GA | 13 (12.7) | 49 (86.0) | 48.99 (18.00−133.3) | <0.001 | 0.004 | 145 (96.0) | 7 (11.7) | 199.6 (60.95−653.6) | <0.001 | 0.004 |
| AA | 0 | 1 (1.8) | N/A | N/A | 6 (4.0) | 53 (88.3) | N/A | N/A | ||
| Dominant (GG vs. GA+AA) | 50.06 (18.43−136.0) | <0.001 | 0.004 | 0 | 0 | 199.6 (60.95−653.6) | <0.001 | 0.004 | ||
| RNF213 4863G>A | ||||||||||
| GG | 78 (76.5) | 51 (89.5) | 1.000 (reference) | 145 (96.0) | 57 (95.0) | 1.000 (reference) | ||||
| GA | 24 (23.5) | 6 (10.5) | 0.395 (0.150−1.039) | 0.060 | 0.120 | 6 (4.0) | 3 (5.0) | 1.340 (0.321−5.592) | 0.688 | 0.688 |
| AA | 0 | 0 | N/A | N/A | 0 | 0 | N/A | N/A | ||
| Dominant (GG vs. GA+AA) | 0.395 (0.150−1.039) | 0.060 | 0.120 | 1.340 (0.321−−5.592) | 0.688 | 0.688 | ||||
| RNF213 4950G>A | ||||||||||
| GG | 91 (89.2) | 49 (86.0) | 1.000 (reference) | 133 (88.1) | 42 (70.0) | 1.000 (reference) | ||||
| GA | 11 (10.8) | 8 (14.0) | 1.260 (0.470−3.379) | 0.646 | 0.672 | 18 (11.9) | 18 (30.0) | 3.096 (1.473−6.506) | 0.003 | 0.006 |
| AA | 0 | 0 | N/A | N/A | 0 | 0 | N/A | N/A | ||
| Dominant (GG vs. GA+AA) | 1.260 (0.470−3.379) | 0.646 | 0.672 | 3.096 (1.473−6.506) | 0.003 | 0.006 | ||||
* Adjusted by age and gender. MMD, moyamoya disease. Abbreviation: AOR, adjusted odd ratio; CI, confidence interval, FDR, false discovery rate; N/A, not application.