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In vivo chondrogenesis of nasal chondrocytes-dendron-functionalized approach. (A) Safranin-O, types II and X collagen staining for control (naïve NC) and dendron-based constructs at 8 weeks in vivo. Dotted white line indicates the cartilaginous part of the dendron based implants. Scale bar = 50 µm. (B) Total GAG production in vivo at 4 and 8 weeks by control (naïve NC) and dendron-based constructs (1 donor, n = 5). * p < 0.01.
