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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Trends Mol Med. 2017 Mar 10;23(4):320–331. doi: 10.1016/j.molmed.2017.02.005

Figure 2. Mitochondrial Sirtuins Coordinate the Stress Response Through Control of Substrate Networks.

Figure 2

Recent research has revealed that mitochondrial sirtuins regulate networks of mitochondrial proteins [9]. Shown are the different mitochondrial programs (bold italic) that are under the control of SIRT3, SIRT4 and SIRT5. Note the diversity of substrates and interaction partners, most notably for SIRT3, and the overlap between substrates and functional groups of substrates between sirtuins. The proteins shown are either experimentally validated as substrates or high-confidence sirtuin interacting proteins. For the complete mitochondrial sirtuin networks, see [9].