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. Author manuscript; available in PMC: 2017 Dec 4.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2016 Apr 12;96(1):119–126. doi: 10.1016/j.ijrobp.2016.04.001

Table 2.

Short and Long Term Toxicity Events1

Toxicity Grade2 I II III IV
Short Term (n=45)
  Weight Gain/Loss 2 (4%) - - -
  Dermatitis3 18 (40%) 19 (42%) 6 (13%) -
  Muscle Weakness - 1 (2%) - -
  Myositis 6 (13%) 1 (2%) - -
  Musculoskeletal Other3 2 (4%) - - 1 (2%)
  Pain from Radiation3 14 (31%) 6 (13%) 2 (4%) -
Long Term (n=44)4
  Bone5 16 (36%) 15 (34%) 1 (2%) 2 (4%)
  Joint5 11 (25%) 10 (23%) 2 (4%) -
  Lung 4 (9%) 2 (4%) - -
  Skin5 23 (52%) 11 (25%) 1 (2%) -
  Spinal cord 2 (4%) - - -
  Subcutaneous Tissue5 21 (48%) 7 (16%) 3 (7%) -
  Secondary Malignancy5 - - - 1 (2%)
1

Highest graded toxicity observed for each patient, in each toxicity category; 45/45 patients developed at least 1 short term toxicity; 40/44 patients developed at least 1 long term toxicity.

2

Common Toxicity Criteria, Version 2.0, including the RTOG/EORTC Late Radiation Morbidity Scoring Scheme.

3

Grade III short term toxicities included radiation dermatitis and pain at the site of radiation. The single grade IV short term toxicity was a fracture at the site of radiation therapy.

4

One patient taken off study < 3months after completion of RT due to distant failure.

5

Grade III long term toxicities included severe pain/tenderness (bone), pain with severe limitation of movement (joint), marked atrophy (skin) and severe induration/loss of subcutaneous tissue (subcutaneous tissue). Grade IV long term toxicities included a fracture at the site of radiation therapy and development of secondary osteosarcoma within the radiation field.