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. 2017 Nov 29;9:731–739. doi: 10.2147/CMAR.S148199

Table 1.

Model parameters used in the simulation

Parameter Everolimus Axitinib
Dose Oral, 10 mg, once daily16 Oral, 5 mg, twice daily 12 h apart17
Adherence 0.76 MPR9 0.76 MPR9
Exposure Median AUC: 127 µg×h/L18 Median AUC: 375 ng×h/mL20
Effect of exposure on outcomes Cmin <10 ng/mL=4.47 median PFS
Cmin 10–30 ng/mL=5.52 median PFS
Cmin >30 ng/mL=5.36 median PFS24 		PFS HR based on AUC level: 0.90920

Abbreviations: AUC, area under the plasma concentration–time curve; Cmin, minimum blood or trough concentration; HR, hazard ratio; MPR, medication possession ratio; PFS, progression-free survival.