Table 1.
Patients’ characteristics
| Variables | Mild emphysema N=6 |
Severe emphysema N=6 |
P-value |
|---|---|---|---|
| Age (years) at the time of the study | 61.7 (7.7) | 61.0 (10.5) | 0.937 |
| Age (years) at diagnosis | 51.2 (4) | 42.7 (6.4) | 0.041 |
| Gender | 0.999 | ||
| Male (%) | 4 (66.7) | 4 (66.7) | |
| Female (%) | 2 (33.3) | 2 (33.3) | |
| Smoking history | 0.135 | ||
| Never (%) | 2 (33.3) | 0 | |
| Current (%) | 0 | 2 (33.3) | |
| Former (%) | 4 (66.7) | 4 (66.7) | |
| FEV1% | 93 (29) | 44 (6.7) | 0.002 |
| AAT blood levels (mg/dL) | 22 (5) | 27 (5.1) | 0.265 |
| Other comorbidities | |||
| Bronchiectasis | 1 (16.7) | 1 (16.7) | 0.098 |
| Cardiovascular diseases | 1 (16.7) | 2 (33.3) | 0.125 |
| Inhaled respiratory treatments (%) | 4 (66.7) | 6 (100) | 0.225 |
| Beta2 agonists (%) | 4 (66.7) | 6 (100) | 0.065 |
| Inhaled corticosteroids (%) | 0 | 6 (100) | 0.025 |
| Replacement therapy (RT) (%) | 2 (33.3) | 4 (66.7) | 0.248 |
| Time from last RT infusion (days) | 15 | 15 | 0.999 |
| Time from blood collection to sample process (minutes) | 74.2 (49.6) | 68.3 (23.2) | 0.589 |
Notes: Data are expressed as mean (SD) or n (valid percentage). Bold values indicate p<0.05.
Abbreviations: AAT, alpha1-antitrypsin; FEV1, forced expiratory volume in 1 s.