Table 2.
Top dysregulated mRNA comparisons in peripheral blood mononuclear cells from severe vs mild AATD emphysema patients
| Symbols | logFC | P-value |
|---|---|---|
| Upregulated | ||
| HLA-DRB5 | 2.46 | 0.025 |
| OLFM4 | 2.42 | 0.003 |
| HBEGF | 2.01 | 0.002 |
| LTF | 1.79 | 0.047 |
| MMP8 | 1.69 | 0.028 |
| CXCL8/IL-8 | 1.57 | 0.019 |
| SOCS3 | 1.56 | 0.000 |
| CAMP | 1.53 | 0.014 |
| G0S2 | 1.50 | 0.015 |
| CCL3L3/CCL3L1 | 1.38 | 0.001 |
| EREG | 1.37 | 0.018 |
| EGR3 | 1.31 | 0.004 |
| NR4A2 | 1.31 | 0.004 |
| OSM | 1.28 | 0.007 |
| CRISP3 | 1.24 | 0.043 |
| IL1B | 1.18 | 0.014 |
| JUP | 1.16 | 0.008 |
| PTGS2 | 1.11 | 0.038 |
| ID1 | 1.11 | 0.003 |
| CLEC5A | 1.10 | 0.003 |
| NR4A3 | 1.08 | 0.027 |
| SNAI1 | 1.00 | 0.003 |
| CD24 | 1.00 | 0.034 |
| Downregulated | ||
| XCL2 | −1.01 | 0.000 |
| PDK4 | −1.01 | 0.047 |
| RNU1–59P | −1.05 | 0.013 |
| ZNF208 | −1.12 | 0.000 |
Note: Table 2 shows different miRNAs using a P-value <0.05 and logFC >±1.
Abbreviations: AATD, alpha1-antitrypsin deficiency; IL-8, interleukin-8; logFC, fold change logarithm; MMP, matrix metalloproteases protease; mRNA, messenger RNA.