Table S2.
ORs ratios for HCC
| Variable | Crude odds ratio
|
Adjusted odds ratio^^
|
||
|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| SSRI drug used | ||||
| No | 1 (reference) | 1 (reference) | ||
| Yes | 0.70 (0.59–0.82) | <0.0001 | 0.60(0.48–0.75) | <0.0001 |
| Sex | ||||
| Female | 1 (reference) | 1 (reference) | ||
| Male | 1.00 (0.93–1.07) | 0.999 | 0.84(0.76–0.92) | 0.0003 |
| Age, years (SD)# | ||||
| 20–29 years | 1 (reference) | 1 (reference) | ||
| 30–39 years | 1.00 (0.80–1.25) | 0.99 | 0.82(0.64–1.05) | 0.1182 |
| 40–49 years | 1.00(0.81–1.23) | 0.99 | 0.69(0.55–0.87) | 0.0019 |
| 50–59 years | 1.00 (0.81–1.23) | 0.99 | 0.62(0.49–0.79) | <0.0001 |
| ≥60 years | 1.00(0.81–1.23) | 0.99 | 0.63(0.49–0.80) | 0.0002 |
| Comorbidity | ||||
| Alcohol-related disease | 3.66 (3.24–4.14) | <0.0001 | 1.04(0.88–1.24) | 0.6209 |
| Cirrhosis | 27.65 (25.18–30.36) | <0.0001 | 26.54(24–29.35) | <0.0001 |
| NAFLD | 0.70 (0.61–0.81) | <0.0001 | 0.78(0.64–0.94) | 0.0104 |
| Hypertension | 0.86 (0.81–0.92) | <0.0001 | 0.93(0.84–1.02) | 0.118 |
| Hyperlipidemia | 0.49 (0.45–0.52) | <0.0001 | 0.49(0.44–0.55) | <0.0001 |
| Biliary stones | 1.46 (1.32–1.63) | <0.0001 | 1.13(0.98–1.31) | 0.0929 |
| CKD | 1.48 (1.33–1.65) | <0.0001 | 1.38(1.18–1.60) | <0.0001 |
| Diabetes | 1.18 (1.10–1.27) | <0.0001 | 1.30(1.17–1.45) | <0.0001 |
| CHF | 1.30 (1.11–1.54) | <0.0001 | 1.18(0.94–1.49) | 0.1609 |
| COPD | 0.58 (0.54–0.63) | <0.0001 | 0.54(0.48–0.61) | <0.0001 |
| Antiviral drugs | ||||
| No | 1 (reference) | 1 (reference) | ||
| Yes | 1.65 (1.50–1.80) | <0.0001 | 2.04(1.70–2.44) | <0.0001 |
| Statin | ||||
| No | 1 (reference) | 1 (reference) | ||
| Yes | 0.69 (0.63–0.75) | <0.0001 | 1.09(0.95–1.26) | 0.2116 |
| Metformin | ||||
| No | 1 (reference) | 1 (reference) | ||
| Yes | 2.30 (1.94–2.74) | <0.0001 | 2.70(2.13–3.44) | <0.0001 |
Notes:
^^
Estimated odds ratio by logistic regression model.
#
2-sample t-test.
Abbreviations: CHF, congestive heart failure; CI, confidence interval; CKD, chronic kidney disease; HCC, hepatocellular carcinoma; NAFLD, nonalcoholic fatty liver disease; OR, odds ratio; SSRI, selective serotonin reuptake inhibitor.