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. Author manuscript; available in PMC: 2017 Dec 4.
Published in final edited form as: Cancer Cell. 2017 Jan 12;31(2):240–255. doi: 10.1016/j.ccell.2016.12.004

Figure 2. Trisomy Impedes the Proliferation of Oncogene-Transduced Cell Lines.

Figure 2

(A) Euploid and trisomic cell lines were stably transduced with plasmids harboring the indicated oncogene or a matched empty vector. Following selection, the cell lines were passaged every third day for up to 10 passages, and the cumulative population doublings over the course of each experiment are displayed. Note that the panel displaying Ts19 + LTa is reproduced in Figure S7. See also Figures S3 and S4.

(B) The number of cells recovered from oncogene-transduced MEFs was divided by the number of cells recovered from vector-transduced MEFs at every passage. Bar graphs display the median ratios and the interquartile ranges. *p < 0.05, **p < 0.005, ***p < 0.0005 (Wilcoxon rank-sum test). See also Figures S3 and S4.