Table 2.
N° patient | MPN | Mutation | Diagnosis /pregnancya | Thrombosis score (IPSET) | Hematological treatment during pregnancy | CHR or MMR |
---|---|---|---|---|---|---|
1 | ET | JAK2V617F | Missed during pregnancy n°1 Given before pregnancy n°2 | HIGH | Interferon during pregnancy n°2 | Yes (n°2) |
2 | ET | JAK2V617F | During | LOW | Interferon during all pregancies | No |
3 | ET | Triple neg | During | LOW | None | No |
4 | ET | Triple neg | During | LOW | None | No |
5 | ET | Triple neg | Missed | LOW | None | No |
6 | ET | JAK2V617F | Missed | LOW | None | No |
7 | ET | JAK2V617F | During | LOW | None | No |
8 | ET | JAK2V617F | Missed during pregnancy n°12 Before for pregnancy n°13 | LOW | Interferon during pregnancy n°13 | Yes |
9 | ET | JAK2V617F | Before | LOW | Interferon | No |
10 | ET | Non JAK2V617F | During | LOW | None | No |
11 | CML | BCR-ABL1 | Before | NA | Interferon | No |
12 | CML | BCR-ABL1 | During | NA | None | No |
13 | CML | BCR-ABL1 | During | NA | None | Yes |
Missed: The diagnosis was missed during pregnancy.
During: MPN was diagnosed during pregnancy; Before: MPN had already been diagnosed; MPN : myeloproliferative neoplasm; ET: essential thrombocytosis; CML: chronic myelogenous leukemia; IPSET: international prognostic score of thrombosis (11);CHR: in case of ET, complete hematological remission; MMR in case of CML: major molecular response. Triple neg : « triple negative » i.e. no mutation found. NonJAK2V617F: means patient was tested only for JAK2V61F and not for CAL-RX and MPL, NA: Not applicable.