Table 1.
Voluntary wheel running performance of female transgenic mice
| Distance (km/day) | Time (h/day) | Speed (km/h) | |
|---|---|---|---|
| Constitutively active GSK-3β | |||
| NTG (n = 9) | 8.49 ± 0.70 | 6.98 ± 0.55 | 1.21 ± 0.04 |
| GSK-3βS9A (n = 14) | 9.92 ± 0.66 | 8.11 ± 0.64 | 1.25 ± 0.03 |
| CaMKII Inhibition | |||
| AC3-C (n = 5) | 4.48 ± 1.28 | 3.22 ± 0.89 | 1.33 ± 0.13 |
| AC3-I (n = 5) | 4.32 ± 0.90 | 3.11 ± 0.66 | 1.29 ± 0.10 |
| Constitutively active GSK-3β and CaMKII Inhibition | |||
| GSK-3βS9A × AC3-C (n = 7) | 7.97 ± 0.54 | 6.74 ± 0.46 | 1.20 ± 0.04 |
| GSK-3βS9A × AC3-I (n = 7) | 7.66 ± 0.77 | 6.23 ± 0.53 | 1.24 ± 0.05 |
| Constitutively active Akt | |||
| NTG (n = 10) | 8.04 ± 0.70 | 5.75 ± 0.52 | 1.39 ± 0.07 |
| myrAkt (n = 9) | 7.12 ± 0.41 | 5.14 ± 0.27 | 1.40 ± 0.06 |
| MEKK1 null | |||
| MEKK1−/− (n = 4) | 4.88 ± 0.82 | 3.81 ± 0.50 | 1.28 ± 0.09 |
| Cyclin D2 null | |||
| NTG (n = 6) | 6.91 ± 0.85 | 5.49 ± 0.60 | 1.25 ± 0.04 |
| Cyclin D2−/− (n = 14) | 5.77 ± 0.81 | 4.63 ± 0.49 | 1.26 ± 0.09 |
Values are mean ± SEM.