Table 3.
Phosphorylation of selected kinases in cyclin D2−/− and NTG female mice exercised for seven days
| Kinase: Phosphorylation site | NTG Ex/Sed (Fold change) | Cyclin D2−/− Ex/ Sed (Fold change) | Cyclin D2−/−/NTG (Fold change) |
|---|---|---|---|
| Src: Y419 | 1.7 | 8.2 | ↑ 4.82 |
| Fyn: Y420 | 1.7 | 4.8 | ↑ 2.82 |
| Yes: Y426 | 1.7 | 4.5 | ↑ 2.65 |
| Hck: Y411 | 0.9 | 2.2 | ↑ 2.44 |
| Chk2: T68 | 1.8 | 3.5 | ↑ 1.94 |
| Fgr; Y412 | 2.1 | 3.6 | ↑ 1.71 |
| TOR: S2448 | 1.6 | 2.2 | 1.38 |
| STAT5b: Y699 | 1.5 | 1.8 | 1.20 |
| STAT5 a/b:Y694/Y699 | 1.8 | 2.1 | 1.17 |
| HSP27: S78/S82 | 2.0 | 2.3 | 1.15 |
| β-catenin | 3.5 | 3.8 | 1.09 |
| Lyn: Y397 | 2.9 | 3.1 | 1.07 |
| STAT6: Y641 | 2.0 | 2.1 | 1.05 |
| STAT2: Y689 | 2.2 | 2.3 | 1.05 |
| FAK: Y397 | 3.7 | 3.7 | 1.00 |
| STAT3: Y705 | 4.5 | 4.5 | 1.00 |
| AMPKα2: T172 | 2.0 | 1.9 | 0.95 |
| GSK-3α/β: S21/S9 | 1.7 | 1.4 | 0.82 |
| CREB: S133 | 3.9 | 3.0 | 0.77 |
| Lck: Y394 | 3.4 | 2.5 | 0.74 |
| MEK1/2: S218/S222, S222/S226 | 2.5 | 1.8 | 0.72 |
| Akt: S473 | 2.1 | 1.5 | 0.71 |
| Pyk2: Y402 | 2.8 | 1.5 | ↓ 0.54 |
| eNOS: s1177 | 2.3 | 1.1 | ↓ 0.48 |
| AMPKα1: t174 | 2.9 | 1.4 | ↓ 0.48 |
| PLCγ-1: Y783 | 3.8 | 1.5 | ↓ 0.39 |
| Paxillin: Y118 | 3.7 | 1.4 | ↓ 0.38 |
| p27: T198 | 3.7 | 1.1 | ↓ 0.30 |
| c-Jun: S63 | 5.9 | 1.3 | ↓ 0.22 |
| p27: T157 | 5.7 | 1.0 | ↓ 0.18 |
| MSK1/2: S376/S360 | 15.5 | 1.8 | ↓ 0.12 |
Note: Bold text indicates an increase in phosphorylation greater than 1.5-fold in both NTG and cyclin D2−/− exercised mice compared to sedentary mice.